4-Methoxyphenylacetic Acid → 3-Bromo-4-methoxyphenylacetic acid

HRID 1622101Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.[Br:13]Br>>[Br:13][C:8]1[CH:7]=[C:6]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:4][C:3]=1[O:2][CH3:1]

Participants

Reactant 2

HCID 76904-Methoxyphenylacetic Acid

HCID 24408Bromine

Product 1

HCID 1366153-Bromo-4-methoxyphenylacetic acidYield 98.9%

Procedure

Proceeding as in Reference 14, but substituting 4-methoxyphenylacetic acid (16.6 g, 0.1 mol) and bromine (16.0 g, 0.1 mol), gave 3-bromo-4-methoxyphenylacetic acid (24.24 g, 98%) as a yellow powder.

Sources & evidence

ORD record: ord-c621a029dde149c3bf557a4ed0682762
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08778625B2

Reaction notes

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