HCID 86607696, compound → HCID 86607717, compound

HRID 1622132Notes

Reaction equation

[C:1]([O:5][C:6](=[O:23])[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][O:17][CH2:18][CH2:19][O:20][CH3:21])=[C:11](Br)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:24][O:25][CH2:26][CH2:27][O:28][CH2:29][O:30][C:31]1[C:38](B2OC(C)(C)C(C)(C)O2)=[CH:37][CH:36]=[CH:35][C:32]=1[CH:33]=[O:34]>>[C:1]([O:5][C:6](=[O:23])[NH:7][CH2:8][C:9]1[CH:10]=[C:11]([C:38]2[CH:37]=[CH:36][CH:35]=[C:32]([CH:33]=[O:34])[C:31]=2[O:30][CH2:29][O:28][CH2:27][CH2:26][O:25][CH3:24])[C:12]([O:15][CH2:16][O:17][CH2:18][CH2:19][O:20][CH3:21])=[CH:13][CH:14]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 86607696HCID 86607696, compound

HCID 86607704HCID 86607704, compound

Product 1

HCID 86607717HCID 86607717, compound

Procedure

Proceeding as in Reference 19, but substituting tert-butyl[3-bromo-4-(2-methoxyethoxymethoxy)-benzyl]carbamate (2.3 g, 5.9 mmol) and 2-(2-methoxyethoxymethoxy)-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzaldehyde (60 mL, 0.1 M in toluene), gave tert-butyl[3′-formyl-6,2′-bis(2-methoxyethoxymethoxy)biphenyl-3-ylmethyl]carbamate (2.96 g).

Sources & evidence

ORD record: ord-53b91b3c3ed8410fb7167df159a111a3
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08778625B2

Reaction notes

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