Triethylamine → HCID 71208520, compound

Participants

Reaction Steps

A mixture of N-hydroxy-4-[5-(4-methanesulfonyl-phenyl)-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxamidine (45 mg), isobutyryl chloride (12 μL), and triethylamine (50 μL) in tetrahydrofuran (5 mL) is stirred for 30 min at room temperature prior to heating to 80° C. for 5 h. The heating is continued over night at reflux. The reaction mixture is diluted with ethyl acetate after cooling to room temperature, washed with water and brine, dried over MgSO4, and concentrated in vacuo. The residue is triturated with a small amount of methanol and the precipitate is filtered off, washed with diethyl ether, and dried to give the title compound. LC (method 5): tR=1.30 min; Mass spectrum (ESI+): m/z=469 [M+H]+.

Provenance & Evidence