Butyryl chloride → HCID 71208671, compound

HRID 1622258Notes

Reaction equation

[OH:1][NH:2][C:3]([N:5]1[CH2:10][CH2:9][CH:8]([CH:11]2[O:29][C:14]3=[CH:15][N:16]=[C:17]([C:19]4[CH:24]=[CH:23][C:22]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:21][CH:20]=4)[CH:18]=[C:13]3[CH2:12]2)[CH2:7][CH2:6]1)=[NH:4].[C:30](Cl)(=O)[CH2:31][CH2:32][CH3:33]>>[CH3:28][S:25]([C:22]1[CH:23]=[CH:24][C:19]([C:17]2[CH:18]=[C:13]3[CH2:12][CH:11]([CH:8]4[CH2:7][CH2:6][N:5]([C:3]5[N:4]=[C:30]([CH2:31][CH2:32][CH3:33])[O:1][N:2]=5)[CH2:10][CH2:9]4)[O:29][C:14]3=[CH:15][N:16]=2)=[CH:20][CH:21]=1)(=[O:27])=[O:26]

Participants

Reactant 2

HCID 8855Butyryl chloride

HCID 178504662HCID 178504662, compound

Product 1

HCID 71208671HCID 71208671, compound

Procedure

The title compound is prepared from N-hydroxy-4-[5-(4-methanesulfonyl-phenyl)-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxamidine and butyryl chloride following a procedure analogous to that described in Example 8. LC (method 5): tR=1.30 min; Mass spectrum (ESI+): m/z=469 [M+H]+.

Sources & evidence

ORD record: ord-8859b653ec15444ea9586ff4d61e9699
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08778926B2

Reaction notes

Loading…