2-Chloro-5-ethylpyrimidine → 2-[1-(5-Ethyl-pyrimidin-2-yl)-piperidin-4-yl]-5-(4-methanesulfonylmethyl-phenyl)-2,3-dihydro-furo[2,3-c]pyridine

HRID 1622260Notes

Reaction equation

HRID 1622260 reaction equation
[CH3:1][S:2]([CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:13]=[C:14]3[CH2:20][CH:19]([CH:21]4[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]4)[O:18][C:15]3=[CH:16][N:17]=2)=[CH:8][CH:7]=1)(=[O:4])=[O:3].Cl[C:28]1[N:33]=[CH:32][C:31]([CH2:34][CH3:35])=[CH:30][N:29]=1>>[CH2:34]([C:31]1[CH:30]=[N:29][C:28]([N:24]2[CH2:25][CH2:26][CH:21]([CH:19]3[O:18][C:15]4=[CH:16][N:17]=[C:12]([C:9]5[CH:10]=[CH:11][C:6]([CH2:5][S:2]([CH3:1])(=[O:4])=[O:3])=[CH:7][CH:8]=5)[CH:13]=[C:14]4[CH2:20]3)[CH2:22][CH2:23]2)=[N:33][CH:32]=1)[CH3:35]

Participants

3

Reactant 2

HCID 35727632-Chloro-5-ethylpyrimidineHCID 679736785-(4-Methanesulfonylmethyl-phenyl)-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine

Product 1

HCID 712089312-[1-(5-Ethyl-pyrimidin-2-yl)-piperidin-4-yl]-5-(4-methanesulfonylmethyl-phenyl)-2,3-dihydro-furo[2,3-c]pyridine

Procedure

The title compound is prepared from 5-(4-methanesulfonylmethyl-phenyl)-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine and 2-chloro-5-ethylpyrimidine following a procedure analogous to that described in Example 1. LC (method 6): tR=1.55 min; Mass spectrum (ESI+): m/z=479 [M+H]+.

Sources & evidence

ORD record
ord-30c1924d339b4682a1e6e82ed69dc32f
Source dataset
uspto-grants-2014_07
Patent number
US08778926B2

Reaction notes

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