HCID 89372981, compound → HCID 71208413, compound

HRID 1622261Notes

Reaction equation

HRID 1622261 reaction equation
[CH3:1][S:2]([CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:13]=[C:14]3[CH2:20][CH:19]([CH:21]4[CH2:26][CH2:25][N:24]([C:27]#[N:28])[CH2:23][CH2:22]4)[O:18][C:15]3=[CH:16][N:17]=2)=[CH:8][CH:7]=1)(=[O:4])=[O:3].[OH:29][NH:30][C:31](=N)[CH:32]([CH3:34])[CH3:33]>>[CH:32]([C:31]1[N:28]=[C:27]([N:24]2[CH2:25][CH2:26][CH:21]([CH:19]3[O:18][C:15]4=[CH:16][N:17]=[C:12]([C:9]5[CH:8]=[CH:7][C:6]([CH2:5][S:2]([CH3:1])(=[O:3])=[O:4])=[CH:11][CH:10]=5)[CH:13]=[C:14]4[CH2:20]3)[CH2:22][CH2:23]2)[O:29][N:30]=1)([CH3:34])[CH3:33]

Participants

3

Reactant 2

HCID 89372981HCID 89372981, compoundHCID 178449908HCID 178449908, compound

Product 1

HCID 71208413HCID 71208413, compound

Procedure

The title compound is prepared from 4-[5-(4-methanesulfonylmethyl-phenyl)-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carbonitrile and N-hydroxy-isobutyramidine following a procedure analogous to that described in Example 2. LC (method 6): tR=1.46 min; Mass spectrum (ESI+): m/z=483 [M+H]+.

Sources & evidence

ORD record
ord-5f56741d706c4002a3c125ce7ffee3ae
Source dataset
uspto-grants-2014_07
Patent number
US08778926B2

Reaction notes

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