HCID 86675674, compound → HCID 71208407, compound

HRID 1622262Notes

Reaction equation

[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[C:13]3[CH2:19][CH:18]([CH:20]4[CH2:25][CH2:24][N:23]([C:26]#[N:27])[CH2:22][CH2:21]4)[O:17][C:14]3=[CH:15][N:16]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[F:28][C:29]([F:35])([F:34])[C:30]([NH:32][OH:33])=N>>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[C:13]3[CH2:19][CH:18]([CH:20]4[CH2:25][CH2:24][N:23]([C:26]5[O:33][N:32]=[C:30]([C:29]([F:35])([F:34])[F:28])[N:27]=5)[CH2:22][CH2:21]4)[O:17][C:14]3=[CH:15][N:16]=2)=[CH:7][CH:6]=1)(=[O:3])=[O:4]

Participants

Reactant 2

HCID 86675674HCID 86675674, compound

HCID 178513417HCID 178513417, compound

Product 1

HCID 71208407HCID 71208407, compound

Procedure

The title compound is prepared from 4-[5-(4-methanesulfonyl-phenyl)-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carbonitrile and 2,2,2-trifluoro-N-hydroxy-acetamidine following a procedure analogous to that described in Example 2. LC (method 5): tR=1.32 min; Mass spectrum (ESI+): m/z=495 [M+H]+.

Sources & evidence

ORD record: ord-4172ea54262342e89742a06c6e984ca1
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08778926B2

Reaction notes

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