Butyryl chloride → HCID 71208642, compound

HRID 1622264Notes

Reaction equation

[OH:1][NH:2][C:3]([N:5]1[CH2:10][CH2:9][CH:8]([CH:11]2[O:30][C:14]3=[CH:15][N:16]=[C:17]([C:19]4[CH:24]=[CH:23][C:22]([CH2:25][S:26]([CH3:29])(=[O:28])=[O:27])=[CH:21][CH:20]=4)[CH:18]=[C:13]3[CH2:12]2)[CH2:7][CH2:6]1)=[NH:4].[C:31](Cl)(=O)[CH2:32][CH2:33][CH3:34]>>[CH3:29][S:26]([CH2:25][C:22]1[CH:23]=[CH:24][C:19]([C:17]2[CH:18]=[C:13]3[CH2:12][CH:11]([CH:8]4[CH2:9][CH2:10][N:5]([C:3]5[N:4]=[C:31]([CH2:32][CH2:33][CH3:34])[O:1][N:2]=5)[CH2:6][CH2:7]4)[O:30][C:14]3=[CH:15][N:16]=2)=[CH:20][CH:21]=1)(=[O:28])=[O:27]

Participants

Reactant 2

HCID 8855Butyryl chloride

HCID 178504864HCID 178504864, compound

Product 1

HCID 71208642HCID 71208642, compound

Procedure

The title compound is prepared from N-hydroxy-4-[5-(4-methanesulfonylmethyl-phenyl)-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxamidine and butyryl chloride following a procedure analogous to that described in Example 8. LC (method 6): tR=1.52 min; Mass spectrum (ESI+): m/z=483 [M+H]+.

Sources & evidence

ORD record: ord-924acf0e2d5c479c945bbb18a55f25b3
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08778926B2

Reaction notes

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