4-[5-(1-Methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2,3-dihydro-furo[2,3-c]pyridine-2-yl]-piperidine-1-carbonitrile → 5-(1-Methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-2,3-dihydro-furo[2,3-c]pyridine

HRID 1622266Notes

Reaction equation

HRID 1622266 reaction equation
[CH3:1][S:2]([N:5]1[CH2:10][CH:9]=[C:8]([C:11]2[CH:12]=[C:13]3[CH2:19][CH:18]([CH:20]4[CH2:25][CH2:24][N:23]([C:26]#[N:27])[CH2:22][CH2:21]4)[O:17][C:14]3=[CH:15][N:16]=2)[CH2:7][CH2:6]1)(=[O:4])=[O:3].[OH:28][NH:29][C:30](=N)[CH2:31][CH2:32][CH3:33]>>[CH3:1][S:2]([N:5]1[CH2:6][CH:7]=[C:8]([C:11]2[CH:12]=[C:13]3[CH2:19][CH:18]([CH:20]4[CH2:25][CH2:24][N:23]([C:26]5[O:28][N:29]=[C:30]([CH2:31][CH2:32][CH3:33])[N:27]=5)[CH2:22][CH2:21]4)[O:17][C:14]3=[CH:15][N:16]=2)[CH2:9][CH2:10]1)(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 866756784-[5-(1-Methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2,3-dihydro-furo[2,3-c]pyridine-2-yl]-piperidine-1-carbonitrileHCID 178449909HCID 178449909, compound

Product 1

HCID 712083925-(1-Methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-2,3-dihydro-furo[2,3-c]pyridine

Procedure

The title compound is prepared from 4-[5-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carbonitrile and N-hydroxy-butyramidine following a procedure analogous to that described in Example 2. LC (method 5): tR=1.02 min; Mass spectrum (ESI+): m/z=474 [M+H]+.

Sources & evidence

ORD record
ord-f46e4eaca1b74e52be8796d33cd7c758
Source dataset
uspto-grants-2014_07
Patent number
US08778926B2

Reaction notes

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