HCID 89372974, compound → HCID 57524502, compound

HRID 1622268Notes

Reaction equation

HRID 1622268 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([CH2:8][S:9]([CH3:12])(=[O:11])=[O:10])[CH:5]=[CH:4][C:3]=1[C:13]1[CH:14]=[C:15]2[CH2:21][CH:20]([CH:22]3[CH2:27][CH2:26][N:25]([C:28]#[N:29])[CH2:24][CH2:23]3)[O:19][C:16]2=[CH:17][N:18]=1.[OH:30][NH:31][C:32](=N)[CH:33]([CH3:35])[CH3:34]>>[F:1][C:2]1[CH:7]=[C:6]([CH2:8][S:9]([CH3:12])(=[O:11])=[O:10])[CH:5]=[CH:4][C:3]=1[C:13]1[CH:14]=[C:15]2[CH2:21][CH:20]([CH:22]3[CH2:27][CH2:26][N:25]([C:28]4[O:30][N:31]=[C:32]([CH:33]([CH3:35])[CH3:34])[N:29]=4)[CH2:24][CH2:23]3)[O:19][C:16]2=[CH:17][N:18]=1

Participants

3

Reactant 2

HCID 89372974HCID 89372974, compoundHCID 178449908HCID 178449908, compound

Product 1

HCID 57524502HCID 57524502, compound

Procedure

The title compound is prepared from 4-[5-(2-fluoro-4-methanesulfonylmethyl-phenyl)-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carbonitrile and N-hydroxy-isobutyramidine following a procedure analogous to that described in Example 2. LC (method 6): tR=1.53 min; Mass spectrum (ESI+): m/z=501 [M+H]+.

Sources & evidence

ORD record
ord-bccf7d688b95407c8c913d8ea5585e7c
Source dataset
uspto-grants-2014_07
Patent number
US08778926B2

Reaction notes

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