HCID 86675689, compound → 5-(4-Methanesulfonyl-phenyl)-2-methyl-2-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-2,3-dihydro-furo[2,3-c]pyridine

HRID 1622273Notes

Reaction equation

HRID 1622273 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[C:13]3[CH2:19][C@:18]([CH:21]4[CH2:26][CH2:25][N:24]([C:27]#[N:28])[CH2:23][CH2:22]4)([CH3:20])[O:17][C:14]3=[CH:15][N:16]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[OH:29][NH:30][C:31](=N)[CH2:32][CH2:33][CH3:34]>>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[C:13]3[CH2:19][C:18]([CH3:20])([CH:21]4[CH2:22][CH2:23][N:24]([C:27]5[O:29][N:30]=[C:31]([CH2:32][CH2:33][CH3:34])[N:28]=5)[CH2:25][CH2:26]4)[O:17][C:14]3=[CH:15][N:16]=2)=[CH:7][CH:6]=1)(=[O:3])=[O:4]

Participants

3

Reactant 2

HCID 86675689HCID 86675689, compoundHCID 178449909HCID 178449909, compound

Product 1

HCID 780367835-(4-Methanesulfonyl-phenyl)-2-methyl-2-[1-(3-propyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-2,3-dihydro-furo[2,3-c]pyridine

Procedure

The title compound is prepared from (S)-4-[5-(4-methanesulfonyl-phenyl)-2-methyl-2,3-dihydro-furo[2,3-c]pyridin-2-yl]-piperidine-1-carbonitrile (Intermediate 33; the configuration of the stereocenter is arbitrarily assigned) and N-hydroxy-butyramidine following a procedure analogous to that described in Example 2. LC (method 6): tR=1.25 min; Mass spectrum (ESI+): m/z=483 [M+H]+.

Sources & evidence

ORD record
ord-363690f57bb344d6ae668196c2841c21
Source dataset
uspto-grants-2014_07
Patent number
US08778926B2

Reaction notes

Loading…