Potassium Carbonate → (S)-5-(1-Methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-methyl-2-[1-(5-methyl-pyrimidin-2-yl)-piperidin-4-yl]-2,3-dihydro-furo[2,3-c]pyridine

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Reaction Steps

The title compound is prepared from (S)-5-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-methyl-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine (Intermediate 41; the configuration of the stereocenter is arbitrarily assigned) and 2-bromo-5-methyl-pyrimidine in dimethylsulfoxide at 100° C. in the presence of potassium carbonate. LC (method 4): tR=0.81 min; Mass spectrum (ESI+): m/z=470 [M+H]+.

Provenance & Evidence