2-Chloro-5-trifluoromethyl-(1,3,4)thiadiazole → (R)-5-(1-Methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-[1-(5-trifluoromethyl-[1,3,4]thiadiazol-2-yl)-piperidin-4-yl]-2,3-dihydro-furo[2,3-c]pyridine

Participants

Reaction Steps

The title compound is prepared from (R)-5-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine (Intermediate 39, the configuration of the stereocenter is arbitrarily assigned) and 2-chloro-5-trifluoromethyl-[1,3,4]thiadiazole following a procedure analogous to that described for Example 79. LC (method 7): tR=1.46 min; Mass spectrum (ESI+): m/z=516 [M+H]+.

Provenance & Evidence