2-Bromo-3-fluoro-5-(trifluoromethyl)pyridine → HCID 71208589, compound

Participants

Reaction Steps

The title compound is prepared from (R)-5-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine (Intermediate 39, the configuration of the stereocenter is arbitrarily assigned) and 2-bromo-3-fluoro-5-trifluoromethyl-pyridine following a procedure analogous to that described for Example 79. LC (method 7): tR=1.75 min; Mass spectrum (ESI+): m/z=527 [M+H]+.

Provenance & Evidence