2-Chloro-5-methoxypyrimidine → HCID 71208046, compound

HRID 1622303Notes

Reaction equation

HRID 1622303 reaction equation
[CH3:1][S:2]([N:5]1[CH2:10][CH:9]=[C:8]([C:11]2[CH:12]=[C:13]3[CH2:19][C@H:18]([CH:20]4[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]4)[O:17][C:14]3=[CH:15][N:16]=2)[CH2:7][CH2:6]1)(=[O:4])=[O:3].Cl[C:27]1[N:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][N:28]=1>>[CH3:1][S:2]([N:5]1[CH2:6][CH:7]=[C:8]([C:11]2[CH:12]=[C:13]3[CH2:19][C@H:18]([CH:20]4[CH2:25][CH2:24][N:23]([C:27]5[N:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][N:28]=5)[CH2:22][CH2:21]4)[O:17][C:14]3=[CH:15][N:16]=2)[CH2:9][CH2:10]1)(=[O:3])=[O:4]

Participants

3

Reactant 2

HCID 5890582-Chloro-5-methoxypyrimidineHCID 71208337(R)-5-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine

Product 1

HCID 71208046HCID 71208046, compound

Procedure

The title compound is prepared from (R)-5-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine (Intermediate 39, the configuration of the stereocenter is arbitrarily assigned) and 2-chloro-5-methoxy-pyrimidine following a procedure analogous to that described for Example 79. LC (method 10): tR=1.48 min; Mass spectrum (ESI+): m/z=472 [M+H]+.

Sources & evidence

ORD record
ord-e3a3d2da6f634cb287d7ded838a43fd5
Source dataset
uspto-grants-2014_07
Patent number
US08778926B2

Reaction notes

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