HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 67339048, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | N-BOC-ethylenediamine | HCID 187201 | — |
| Reactant | 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid | HCID 392871 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67339048 | HCID 67339048 | 97.4% |
Reaction Steps
General procedure A was followed using N-Boc-isonipecotic acid (0.20 g, 0.86 mmol), HATU (0.43 g, 1.1 mmol), DIPEA (0.76 mL, 4.4 mmol), N-Boc-ethylenediamine (0.18 g, 1.1 mmol) and DMF (4 mL) to furnish the title compound as a beige solid (311 mg, 96%), m.p. 172-174° C.; umax (CHCl3)/cm−1 3022, 2981, 1684, 1671, 1507, 1367, 1241, 1165; m/z (ESI) C18H33N3NaO5 requires 394.2312, found [M+Na]+ 394.2310.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08778925B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-0b87e0a2a649462d8a7edff588e4a14d |
| Source note | uspto-grants-2014_07 |