Triethylamine → HCID 58378283, compound

Participants

Reaction Steps

General procedure C (See Example 1) was followed using benzyl-4-(piperidine-4-carbonyl)piperazine-1-carboxylate 12 (0.11 g, 0.33 mmol), 3,4,5-trichloropyridine (61 mg, 0.33 mmol), NMP (2.5 mL) and triethylamine (93 μL, 0.66 mmol). The crude product was purified by flash column chromatography on silica gel (hexane, EtOAc, 1:1) to furnish the title compound 13 as a white solid (58 mg, 36%), umax (CHCl3)/cm−1 3023, 1699, 1635, 1559, 1432, 1285, 1232, 1015; m/z (ESI) C23H27Cl2N4O3 requires 477.1455, found [M+H]+ 477.1457.

Provenance & Evidence