HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1622331Generated: October 28, 2026
Phosphorus oxychloride → HCID 53408117, compound
https://huagongshe.com/reaction/1622331
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 5-Bromopyrimidin-2(1H)-one--hydrogen bromide (1/1) | HCID 12795533 | — |
| Product | HCID 53408117 | HCID 53408117 | — |
Reaction Steps
A suspension of 5-bromopyrimidone hydrobromide (1.0 g, 3.9 mmol) in phosphorous oxychloride (4 mL) was heated at 90° C. for 1 h then cooled 0° C. The mixture was filtered, washed with POCl3 (2×2 mL) to furnish the title compound as a cream solid (388 mg). This compound was unstable to air and was used immediately in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08778925B2 |
|---|
| Source dataset | uspto-grants-2014_07 |
|---|
| ORD ID | ord-688f370ec4aa487a9a170614f2ba51b7 |
|---|
| Source note | uspto-grants-2014_07 |
|---|
