Phosphorus oxychloride → 4-Chloro-5-methylpyrimidine hydrochloride

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-methyl-3H-pyrimidin-4-one (0.60 g, 3.6 mmol) and phosphorous oxychloride (2.0 mL) was heated at 90° C. for 2.5 h. The mixture was evaporated to dryness under reduced pressure and the resultant solid was purified by sublimation under reduced pressure to furnish the title compound as a white solid. This compound was unstable to air and was used immediately in the next step.

Provenance & Evidence