Trimethylsilyl iodide → HCID 45275136, compound

Participants

Reaction Steps

To a solution of benzyl-4-(1-(3,5-dichloropyridin-4-yl)piperidine-4-carbonyl)piperazine-1-carboxylate 13 (40 mg, 0.080 mmol) in DCM (1 mL), cooled to 0° C. was added trimethylsilyliodide (24 μL, 0.16 mmol) and the solution was stirred at this temperature for 90 min, after which time trimethylsilyl iodide (48 μL, 0.32 mmol) was added and the mixture warmed to room temperature. After stirring for a further 45 min, the solution was concentrated under reduced pressure and the crude product was purified on an SCX-2 cartridge (MeOH followed by 0.5 M NH3 in MeOH) to furnish the title compound as a yellow solid (27 mg, 94%), m.p. 256-258° C.; m/z (ESI) C15H20C12N4NaO requires 365.0906, found [M+Na]+ 365.0909.

Provenance & Evidence