Sodium Hydroxide → HCID 45275137, compound

Participants

Reaction Steps

A solution of 1-(3,5-dichloropyridin-4-yl)pyrrolidine-3-carbonitrile 14 (83 mg, 0.34 mmol) in sulphuric acid (3 mL) was stirred for 90 min and then poured onto ice/water (100 g). The mixture was made basic by the addition of a 2 M solution of sodium hydroxide and extracted with EtOAc (2×50 mL). The combined organic extracts were washed with water (50 mL), brine (50 mL), dried (MgSO4) and concentrated under reduced pressure, to furnish the title compound as a white solid (65 mg, 73%), m.p. 161-163° C.; umax (CHCl3)/cm−1 3053, 2985, 1689, 1558, 1465; m/z (ESI) C10H12Cl2N3O requires 260.0352 found [M+H]+ 260.0355.

Provenance & Evidence