4-Piperidinecarboxamide → HCID 45275244, compound

Participants

Reaction Steps

A solution of 4-chloro-3,5-dimethylpyridine hydrochloride (0.10 g, 0.56 mmol) and isonipecotamide (0.22 mg, 1.7 mmol) in water (1.5 mL) was heated at 175° C. for 60 min, in a microwave reactor. The mixture was poured into a saturated solution of sodium hydrogen carbonate (20 mL), extracted with EtOAc (2×20 mL). The combined organic extracts were dried (MgSO4) and concentrated under reduced pressure. The crude product was purified by flash column chromatography on silica gel (CH2Cl2, MeOH, 95:5) to furnish the title compound as a white solid (5 mg, 4%), m/z 234 (100%, [M+H]+); m/z (ESI) C13H20N3O requires 234.1601 found [M+H]+ 234.1600.

Provenance & Evidence