Potassium Acetate → HCID 45275351, compound

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Reaction Steps

A mixture of 1-(2-chloro-5-phenylpyrimidin-4-yl)piperidine-4-carboxamide E32 (35 mg, 0.11 mmol), potassium acetate (22 mg, 0.22 mmol) and 10% wt palladium on carbon (3.5 mg) in acetic acid (2 mL) was stirred under an atmosphere of hydrogen (1 atm) for 18 h. The mixture was filtered through celite, washed with AcOH (2×10 mL) and concentrated under reduced pressure. The crude product was purified by preparative tlc on silica gel (CH2Cl2/MeOH, 10:1) to furnish the title compound as a white solid (9 mg, 29%) m/z 283 (100%, [M+H]+); m/z (ESI) C16H19N4O requires 283.1553 found [M+H]+ 283.1549.

Provenance & Evidence