4-Piperidinecarboxamide → HCID 45275354, compound

Participants

Reaction Steps

General procedure C was followed using 3-bromo-4-chloro-pyridine (0.10 g, 0.52 mmol) and isonipecotamide (67 mg, 0.52 mmol) NMP (2 mL) and triethylamine (0.14 mL, 1.0 mmol). The crude product was purified by flash column chromatography on silica gel (CH2Cl2, MeOH, gradient 99:1 to 95:5) to furnish the title compound as a white solid (49 mg, 33%), LC-MS (ESI) Rt 0.80 min, m/z 284 (100%, [M+H]+); m/z (ESI) C11H15BrN3O requires 284.0393 found [M+H]+ 284.0392.

Provenance & Evidence