Sodium Carbonate → HCID 45275355, compound

Participants

Reaction Steps

General procedure D (See Example 4) was followed using 1-(3-bromopyridin-4-yl)piperidine-4-carboxamide E36 (50 mg, 0.17 mmol), 4-methoxyphenylboronic acid (32 mg, 0.21 mmol), tetrakis (triphenylphosphine)palladium(0) (10 mg, 5 mol %), acetonitrile (1.2 mL) and 0.5 M sodium carbonate (0.49 mL, 0.25 mmol) for 50 min. The crude product was purified by flash column chromatography on silica gel (CH2Cl2, MeOH, gradient 97:3 to 95:5) to furnish the title compound as a white solid (49 mg, 89%), LC-MS (ESI) Rt 1.28 min, m/z 312 (100%, [M+H]+); m/z (ESI) C18H22N3O2 requires 312.1706 found [M+H]+ 312.1705.

Provenance & Evidence