Sodium Carbonate → HCID 45275573, compound

Participants

Reaction Steps

General procedure D was followed using 1-(3-bromopyridin-4-yl)piperidine-4-carboxamide E36 (25 mg, 0.088 mmol), 4-fluoro-3-methylphenylboronic acid (16 mg, 0.11 mmol), tetrakis(triphenylphosphine)palladium(0) (5 mg, 5 mol %), 0.5 M sodium carbonate (0.25 mL, 0.12 mmol) and acetonitrile (1 mL) for 50 min. The crude product was purified by preparative tlc (CH2Cl2, MeOH, 10:1) to furnish the title compound as a white solid (15 mg, 56%), LC-MS (ESI 3.5 min) Rt 1.46 min, m/z 314 (100%, [M+H]+); m/z (ESI) C18H21FN3O requires 314.1663 found [M+H]+ 314.1658.

Provenance & Evidence