Sodium Carbonate → HCID 45275577, compound

Participants

Reaction Steps

General procedure D was followed using 1-(3,5-dichloropyridin-4-yl)piperidine-4-carboxamide 23 (24 mg, 0.088 mmol), pyrimidin-5-yl boronic acid (12 mg, 0.11 mmol) and tetrakis(triphenylphosphine)palladium(0) (5 mg, 5 mol %), acetonitrile (1 mL) and a 0.5 M sodium carbonate (0.25 mL, 0.12 mmol) for 30 min. The crude product was purified by preparative tlc on silica gel (CH2Cl2, MeOH, 10:1) to furnish the title compound as a white solid (26 mg, 95%), LC-MS (ESI, 3.5 min) Rt 1.19 min, m/z 318 (100%, [M+H]+); m/z (ESI) C15H17ClN5O requires 318.1116 found [M+H]+ 318.1114.

Provenance & Evidence