Sodium Carbonate → HCID 45275672, compound

Participants

Reaction Steps

General procedure D was followed using 1-(3-bromopyridin-4-yl)piperidine-4-carboxamide E36 (17 mg, 0.060 mmol), thiophene-3-boronic acid (9.2 mg, 0.072 mmol), tetrakis(triphenylphosphine)palladium(0) (3.5 mg, 5 mol %), 0.5 M sodium carbonate (0.17 mL, 0.084 mmol) and acetonitrile (1 mL) for 50 min. The crude product was purified by preparative tlc (CH2Cl2, MeOH, 10:1) to furnish the title compound as a white solid (13 mg, 76%), LC-MS (ESI, 3.5 min) Rt 1.12 min, m/z 288 (100%, [M+H]+); m/z (ESI) C15H18N3OS requires 288.1165 found [M+H]+ 288.1163.

Provenance & Evidence