Triethylamine → HCID 45275676, compound

Participants

Reaction Steps

General procedure C was followed using 3,4,5-trichloropyridine (50 mg, 0.27 mmol), piperidin-4-ylmethanol (35 mg, 0.30 mmol), triethylamine (76 μL, 0.54 mmol) and NMP (1.5 mL). The crude product was purified by flash column chromatography on silica gel (hexane, EtOAc, 85:15) to furnish the title compound as white solid (51 mg, 71%), LC-MS (ESI, 3.5 min) Rt 2.49 min, m/z 261 (100%, [M+H]+); m/z (ESI) C11H15Cl2N2O requires 261.0556 found [M+H]+ 261.0558; HPLC Rt 6.68 min, 100%.

Provenance & Evidence