Potassium Phosphate, Tribasic → HCID 45275782, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 1-(3-bromopyridin-4-yl)piperidine-4-carboxamide E36 (20 mg, 0.070 mmol), phenylboronic acid (17 mg, 0.14 mmol) and tetrakis (triphenylphosphine)palladium(0) (8 mg, 10 mol %) in toluene (1.5 mL) was added a 0 potassium phosphate (45 mg, 0.21 mmol). The mixture was heated at 170° C. in a microwave reactor for 45 min, then poured into a saturated solution of sodium hydrogen carbonate (25 mL). The mixture was extracted with EtOAc (2×20 mL) and the combined organic extracts were washed with brine (25 mL), dried (MgSO4) and the solvent was removed under reduced pressure. The crude product was purified by flash column chromatography on silica gel (CH2Cl2, MeOH, 95:5) to furnish the title compound as a white solid (5 mg, 25%), LC-MS (ESI, 3.5 min) Rt 1.28 min, m/z 282 (100%, [M+H]+), m/z (ESI) C17H20N3O requires 282.1601 found [M+H]+ 282.1597.

Provenance & Evidence