Sodium Carbonate → HCID 45275882, compound

Participants

Reaction Steps

General procedure D was followed using 1-(3,5-dichloropyridin-4-yl)piperidine-4-carboxamide 23 (24 mg, 0.088 mmol), 3,4-difluorobenzene boronic acid (17 mg, 0.11 mmol), tetrakis(triphenylphosphine)palladium(0) (5 mg, 5 mol %), acetonitrile (1 mL) and 0.5 M sodium carbonate (0.25 mL, 0.12 mmol) for 30 min. The crude product was purified by preparative tlc on silica gel (CH2Cl2, MeOH, 10:1), to give impure title compound as a white solid (16 mg) followed by preparative hplc (CH3CN, H2O, gradient 1:9 to 9:1) to furnish the title compound as a white solid, LC-MS (ESI, 3.5 min) Rt 1.91 min, m/z 352 (100%, [M+H]+); m/z (ESI) C17H16ClF2N3O requires 352.1023 found [M+H]+ 352.1017.

Provenance & Evidence