Diethyl Ether → HCID 178477739, compound

HRID 1622433Notes

Reaction equation

HRID 1622433 reaction equation
[CH:1]1([NH:4][C:5]([NH:7][C:8]2[C:9]([C:13]3[NH:17][C:16]4[CH:18]=[CH:19][C:20]([CH2:22][N:23]5[CH2:28][CH2:27][O:26][CH2:25][CH2:24]5)=[CH:21][C:15]=4[N:14]=3)=[N:10][NH:11][CH:12]=2)=[O:6])[CH2:3][CH2:2]1.[CH2:29]([S:31]([OH:34])(=[O:33])=[O:32])[CH3:30].CCOCC>CO.CCOC(C)=O.CO>[CH2:29]([S:31]([OH:34])(=[O:33])=[O:32])[CH3:30].[CH:1]1([NH:4][C:5]([NH:7][C:8]2[C:9]([C:13]3[NH:17][C:16]4[CH:18]=[CH:19][C:20]([CH2:22][N:23]5[CH2:24][CH2:25][O:26][CH2:27][CH2:28]5)=[CH:21][C:15]=4[N:14]=3)=[N:10][NH:11][CH:12]=2)=[O:6])[CH2:3][CH2:2]1

Participants

6

Reactant 3

HCID 3283Diethyl EtherHCID 11668Ethanesulfonic acidHCID 178522431HCID 178522431, compound

Product 1

HCID 178477739HCID 178477739, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 21584119Ethylacetate methanolSolvent

Procedure

To a solution of 1-cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea free base in MeOH-EtOAc was added 1 equivalent of ethanesulfonic acid. The mixture was stirred at ambient temperature and then reduced in vacuo. The residue was taken up in MeOH and to the solution was added Et2O. Mixture left to stand for 72 h and the solid formed collected by filtration and dried to give 1-cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea ethanesulfonate salt.

Workup

  1. waitMixture left
  2. customthe solid formed
  3. filtrationcollected by filtration
  4. customdried

Sources & evidence

ORD record
ord-d2878037af01467d9e72c2e17980fc08
Source dataset
uspto-grants-2014_07
Patent number
US08778936B2

Reaction notes

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