HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Imidazo[1,2-a]pyrazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide → Ponatinib
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Imidazo[1,2-a]pyrazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide | HCID 24826558 | — |
| Reactant | 3-Ethynylimidazo[1,2-b]pyridazine | HCID 46838760 | — |
| Product | Ponatinib | HCID 24826799 | — |
Reaction Steps
The title compound was synthesized in a manner similar to that described for Example 14, from 3-ethynylimidazo[1,2-b]pyridazine and 3-iodo-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (Prepared as described in Example 2). The product was obtained as a solid: 533 m/z (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08778942B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-5919f8068cdf47e4af69f481ab690787 |
| Source note | uspto-grants-2014_07 |