Hydrochloric Acid → (S)-(3-(prop-1-yn-1-yl)pyridin-2-yl)(4-(trifluoromethyl)phenyl)methanamine hydrochloride
Reaktionsgleichung
C(OC(=O)[NH:7][C@H:8]([C:19]1[C:24]([C:25]#[C:26][CH3:27])=[CH:23][CH:22]=[CH:21][N:20]=1)[C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=1)(C)(C)C.[ClH:29]>C(Cl)Cl>[ClH:29].[C:25]([C:24]1[C:19]([C@H:8]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:16])[F:17])=[CH:11][CH:10]=2)[NH2:7])=[N:20][CH:21]=[CH:22][CH:23]=1)#[C:26][CH3:27]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 23 °C
Versuchsvorschrift
To a round bottom flask containing (S)-tert-butyl((3-(prop-1-yn-1-yl)-pyridin-2-yl)(4-(trifluoromethyl)phenyl)methyl)carbamate (400 mg, 1.025 mmol) was added DCM (8 mL). The resulting mixture was stirred at 23° C. for 2 min. Hydrogen chloride (4 mL, 4 N in 1,4-dioxane) was then added via syringe. The reaction was then stirred for 3 h and then the volatiles were removed via rotary evaporator. The solid was placed on high vacuum overnight to give (S)-(3-(prop-1-yn-1-yl)pyridin-2-yl)(4-(trifluoromethyl)phenyl)methanamine hydrochloride as a white solid.
Aufarbeitung
- stirringThe reaction was then stirred for 3 h
- customthe volatiles were removed via rotary evaporator
- customwas placed on high vacuum overnight
Quellen und Nachweise
- ORD-Eintrag
- ord-d3b88c4774f24005823928103b974060
- Quelldatensatz
- uspto-grants-2014_07
- Patentnummer
- US08778941B2
Notizen zur Reaktion
Wird geladen…