Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 9-[4-(1-Methylethoxy)phenyl]-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Ethanesulfonylchloride, 2-chloro- | HCID 15385 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 3-(4-Isopropoxyphenyl)pyridin-2-amine | HCID 64087698 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 9-[4-(1-Methylethoxy)phenyl]-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide | HCID 66747896 | 73.7% |
반응 단계
A mixture of 3-[4-(1-methylethoxy)phenyl]pyridin-2-amine (350 mg) in dehydrated THF (5 mL) was added to a mixture of sodium hydride (60%, 307 mg) and 2-chloroethanesulfonyl chloride (750 mg) in dehydrated THF (5 mL) under ice-cooling. The reaction mixture was stirred at room temperature overnight, and water and hexane were added. The resulting precipitate was collected by filtration, and washed with water and diisopropyl ether to give the title compound (360 mg) as a white solid. The obtained solid was crystallized from THF, acetonitrile and diisopropyl ether to give a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08778934B2 |
| 출처 데이터셋 | uspto-grants-2014_07 |
| ORD ID | ord-1abb929204b74b7b9cbf90fcb06fa075 |
| 출처 메모 | uspto-grants-2014_07 |