Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 9-[4-(3-Chlorophenoxy)phenyl]-3,4,6,7,8,9-hexahydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | (3-Chlorophenyl)boronic acid | HCID 2734323 | — |
| 반응물 | 4-(2,2-Dioxido-3,4,6,7,8,9-hexahydropyrido[2,1-c][1,2,4]thiadiazin-9-yl)phenol | HCID 66747720 | — |
| 촉매 | HCID 178476681 | HCID 178476681 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 9-[4-(3-Chlorophenoxy)phenyl]-3,4,6,7,8,9-hexahydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide | HCID 66823737 | 26.5% |
반응 단계
A mixture of 3-chlorophenylboronic acid (167 mg), 4-(2,2-dioxido-3,4,6,7,8,9-hexahydropyrido[2,1-c][1,2,4]thiadiazin-9-yl)phenol (100 mg), diacetoxycopper (130 mg), triethylamine (0.248 mL), and powdered 4A MS (1.00 g) in MeCN (10 mL) was stirred at room temperature overnight. The mixture was added with NH silica gel, concentrated in vacuo, and purified by column chromatography (NH silica gel, eluted with MeOH in EtOAc), and then recrystallized from EtOAc-IPE to give the title compound (37.0 mg) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08778934B2 |
| 출처 데이터셋 | uspto-grants-2014_07 |
| ORD ID | ord-63f7daeafcce40c38b80f0a124261db4 |
| 출처 메모 | uspto-grants-2014_07 |