Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triphenylphosphine → 3-((4-Cyclopentylphenoxy)methyl)pyridin-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 4-Cyclopentylphenol | HCID 15202 | — |
| 반응물 | Diisopropyl azodicarboxylate | HCID 5363146 | — |
| 반응물 | (2-Aminopyridin-3-yl)methanol | HCID 11159325 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-((4-Cyclopentylphenoxy)methyl)pyridin-2-amine | HCID 68280929 | 8.5% |
반응 단계
Diisopropylazodicarboxylate (0.714 mL) was added to a solution of triphenylphosphine (951 mg), (2-aminopyridin-3-yl)methanol (300 mg) and 4-cyclopentylphenol (392 mg) in THF (dry) (20 mL) at room temperature and the mixture was stirred for 20 hr. Volatiles were removed in vacuo with silica-gel. The silica-supported mixture was purified by column chromatography (1st; NH-silica gel, eluted with EtOAc in hexane, 2nd; silica gel, eluted with EtOAc in hexane) to give the title compound (55.4 mg) as a white powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08778934B2 |
| 출처 데이터셋 | uspto-grants-2014_07 |
| ORD ID | ord-f1e9f55f526b4aeb97f498aee487372d |
| 출처 메모 | uspto-grants-2014_07 |