Hydrochloric Acid → HCID 46832948, compound

Participants

Reaction Steps

The 5-(2-(4-(2-methoxyphenyl)piperazin-1-yl)propanoyl)indolin-2-one hydrochloride (1.66 g, 4 mmol) was dissolved in 50 ml of methanol solution, and sodium borohydride (0.15 g, 8.4 mmol) was added in proportions, mixed and stirred at room temperature for 3 hours. Working up according to general procedure B gave 0.55 g of (1RS,2SR)-5-(1-hydroxy-2-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)indolin-2-one (IV-1) hydrochloride having a melting point of 213 to 215° C., with a yield of 32.9%; and 0.51 g of (1RS,2RS)-5-(1-hydroxy-2-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)indolin-2-one (IV-2) hydrochloride having a melting point of 237 to 239° C., with a yield of 30.5%.

Provenance & Evidence