1-(2-Methoxyphenyl)piperazine → HCID 67999698, compound

Participants

Reaction Steps

5-(2-chloropropyl)-1H-benzimidazol-2-one was prepared from 1H-benzimidazol-2-one according to the synthetic and working-up method of general procedure B. 5-(2-chloropropyl)-1H-benzimidazol-2-one (2.47 g, 0.011 mol) and 2-methoxyphenyl piperazine (1.92 g, 0.01 mol) were dissolved in 100 ml of acetonitrile, and triethylamine (3.04 g, 0.03 mol) was added. A reaction under refluxing was allowed to proceed for 3 hours at an elevated temperature. Working up according to general procedure B gave 3.73 g of 5-(2-(4-(2-methoxy phenyl)piperazin-1-yl)propanoyl)-1H-benzo[d]imidazol-2(3H)-one hydrochloride. The yield was 89.5%.

Provenance & Evidence