Hydrochloric Acid → HCID 46832949, compound

Participants

Reaction Steps

The 5-(2-(4-(2-methoxyphenyl)piperazin-1-yl)propanoyl)-1H-benzo[d]imidazol-2(3H)-one hydrochloride (1.67 g, 4 mmol) was dissolved in 50 ml of methanol solution, and sodium borohydride (0.15 g, 8.4 mmol) was added in proportions, mixed and stirred at room temperature for 3 hours. Working up according to general procedure B gave 0.57 g of (1RS, 2SR)-5-(1-hydroxy-2-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2(3H)-one (IV-3) hydrochloride having a melting point of 221 to 223° C., with a yield of 34.0%; and 0.50 g of (1RS,2RS)-5-(1-hydroxy-2-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2(3H)-one (IV-4) hydrochloride having a melting point of 242 to 244° C., with a yield of 29.8%.

Provenance & Evidence