Hydrochloric Acid → HCID 46832950, compound

Participants

Reaction Steps

The 6-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propanoyl)benzo[d]thiazol-2(3H)-one hydrochloride (1.89 g, 4 mmol) was dissolved in 50 ml of methanol solution, and sodium borohydride (0.15 g, 8.4 mmol) was added in proportions, mixed and stirred at room temperature for 3 hours. Working up according to general procedure B gave 0.61 g of (1RS, 2SR)-6-(1-hydroxy-2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propyl)benzo[d]thiazol-2(3H)-one (IV-5) hydrochloride having a melting point of 217 to 219° C., with a yield of 32.2%; and 0.57 g of (1RS,2RS)-6-(1-hydroxy-2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propyl)benzo[d]thiazol-2(3H)-one (IV-6) hydrochloride having a melting point of 235 to 237° C., with a yield of 30%.

Provenance & Evidence