Acetic Anhydride → HCID 59600588, compound

HRID 1622915Notes

Reaction equation

HRID 1622915 reaction equation
[CH3:1][O:2][C:3](=[O:20])[C:4]1[C:9]([OH:10])=[C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:7]([CH3:19])=[N:6][CH:5]=1.[C:21](OC(=O)C)(=[O:23])[CH3:22]>>[CH3:1][O:2][C:3](=[O:20])[C:4]1[C:9]([O:10][C:21](=[O:23])[CH3:22])=[C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:7]([CH3:19])=[N:6][CH:5]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 178498802HCID 178498802, compound

Product 1

HCID 59600588HCID 59600588, compoundYield 90%

Procedure

After a solution of the compound 5 (19.1 g, 70 mmol) in acetic anhydride (134 ml) was stirred at 130° C. for 40 minutes, the solvent was distilled off under reduced pressure to obtain 4-acetoxy-5-benzyloxy-6-methyl-nicotinic acid methyl ester 6 (19.9 g, 90%) as a flesh colored crystal.

Workup

  1. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-11aa99ec40a646449106813389d4f4c8
Source dataset
uspto-grants-2014_07
Patent number
US08778943B2

Reaction notes

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