Triethylamine → HCID 66922753, compound

Participants

Reaction Steps

To a solution of {4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}acetic acid (Intermediate 5) (0.1 g, 0.26 mmol) in DCM/DMF (1:1, 6 ml) were added EDCI (0.055 g, 0.29 mmol), DMAP (0.003 g, 0.03 mmol) and triethylamine (40 μl, 0.29 mmol) followed by the addition of cyclopentyl 2-methylalaninate hydrochloride (Intermediate 7) (0.059 g, 0.29 mmol). The mixture was stirred at RT overnight. The reaction mixture was diluted with EtOAc (20 ml), washed with water (2×20 ml), brine (20 ml) then dried (MgSO4), filtered and concentrated under reduced pressure to leave a yellow oil. Purification by column chromatography (100% EtOAc) afforded the title compound as a pale yellow solid (68 mg, 48%)

Provenance & Evidence