tert-Butyl 2-methylalaninate → HCID 66922528, compound
Reaction equation
[NH2:1][C:2]1[N:7]([C:8]2[C:13]([F:14])=[CH:12][C:11]([CH2:15][CH:16]=O)=[CH:10][C:9]=2[F:18])[C:6](=[O:19])[CH:5]=[CH:4][C:3]=1[C:20](=[O:29])[C:21]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=1[F:28].[CH3:30][C:31]([C:34]([O:36]C(C)(C)C)=[O:35])([CH3:33])[NH2:32]>>[NH2:1][C:2]1[N:7]([C:8]2[C:13]([F:14])=[CH:12][C:11]([CH2:15][CH2:16][NH:32][C:31]([CH3:30])([C:34]([OH:36])=[O:35])[CH3:33])=[CH:10][C:9]=2[F:18])[C:6](=[O:19])[CH:5]=[CH:4][C:3]=1[C:20](=[O:29])[C:21]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=1[F:28]Participants
3
Procedure
Example 12 was synthesised using Intermediate 4 and Intermediate 8 following the same synthetic route as Example 11 (Scheme 12).
Workup
- customExample 12 was synthesised
Sources & evidence
- ORD record
- ord-460e229869c94669b8fda0548df96892
- Source dataset
- uspto-grants-2014_07
- Patent number
- US08778953B2
Reaction notes
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