Dimethyl Sulfoxide → HCID 136332407, compound

Participants

Reaction Conditions

Reaction Steps

Process 2: Sodium hydrogen carbonate (2.02 mg, 24.0 mmol) was added to a dimethyl sulfoxide (20 mL) solution of hydroxyl amine hydrochloride (1.42 g, 20.4 mmol), and the reaction solution was stirred at 40° C. for 1 hour. The reaction solution was added a dimethyl sulfoxide (3 mL) solution of 2-{5-{[4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl]methyl}pyridin-2-yl}benzonitrile (430 mg, 0.987 mmol), and stirred at 90° C. for 19 hours. The reaction solution was added water and extracted with ethyl acetate. The organic layer was combined, washed with water and brine, dried over anhydrous sodium sulfate, and concentrated in vacuo. The residues obtained were subjected to silica gel column chromatography (ethyl acetate), to obtain 2-{5-{[4-butyl-2-methyl-6-oxo-1-(pyridin-2-yl)-1,6-dihydropyrimidin-5-yl]methyl}pyridin-2-yl}-N′-hydroxybenzimidamide (430 mg, 93%) as a white solid.

Provenance & Evidence