HCID 57455387, compound → HCID 86612242, compound

Participants

Reaction Steps

Catalyst (0.78 g of 5% platinum on carbon) was added to a suspension of (4,4-diethoxybutyl)(3-nitro[1,5]naphthyridin-4-yl)amine (7.8 g, 23.3 mmol) in ethyl acetate (100 mL). The mixture was placed under hydrogen pressure ((30 psi (2.1×105 Pa)) for 2 hours. The reaction mixture was filtered through a layer of CELITE filter aid and the filter cake was rinsed with ethyl acetate (40 mL). The filtrate was concentrated under reduced pressure to provide N4-(4,4-diethoxybutyl)[1,5]naphthyridine-3,4-diamine as a thick yellow oil which was carried on to the next without further purification.

Provenance & Evidence