Sodium Hydroxide → HCID 57455390, compound

Participants

Reaction Steps

Aqueous sodium hydroxide (6M, 4 mL, 24 mmol, 2 eq) was added to a solution of ethyl 4-(2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butyrate (4.1 g, 12.0 mmol, 1.0 eq) in ethanol (50 mL) and stirred overnight at ambient temperature. The reaction mixture was concentrated under reduced pressure, dissolved in water (15 mL) and adjusted to a pH of 4. The precipitate was filtered and dried at 65° C. under vacuum to afford 3.53 g of 4-(2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)butyric acid as a tan powder.

Provenance & Evidence