Phenyl isocyanate → HCID 86612253, compound

Participants

Reaction Steps

The preparation of O-methyl-N-[1-methyl-4-(2-propyl-1H-imidazo-[4,5-c]quinolin-1-yl)butyl]hydroxylamine is described in parts A-D of Example 10. Phenyl isocyanate (0.49 mL, 4.59 mmol) was added to a solution of O-methyl-N-[1-methyl-4-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]hydroxylamine (1.0 g, 3.06 mmol) in tetrahydrofuran (THF) (20 mL) and stirred for 4 hours at ambient temperature. The reaction mixture was concentrated under reduced pressure to afford 1.02 g of 1-[4-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)-1-methylbutyl]-1-methoxy-3-phenylurea which was used without any further purification.

Provenance & Evidence