Ethyl isocyanate → HCID 86612254, compound

Participants

Reaction Steps

Ethyl isocyanate (0.49 mL, 4.59 mmol) was added to a solution of O-methyl-N-[1-methyl-4-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]hydroxylamine (0.600 g, 1.83 mmol) in tetrahydrofuran (THF) (25 mL) at 0° C. and stirred for 1 hour at ambient temperature. Analysis by LC-MS showed the reaction was incomplete and additional ethyl isocyanate (0.19 mL) was added to the reaction mixture. After 1 hour of stirring at ambient temperature, the reaction mixture was concentrated under reduced pressure to afford 0.700 g of 1-[4-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)-1-methylbutyl]-3-ethyl-1-methoxyurea.

Provenance & Evidence