Water → HCID 69507133, compound

Participants

Reaction Steps

Water (200 mL), sodium hydrosulfite (90.9 g, 522.3 mmol), ethyl viologen dibromide (0.64 g, 1.74 mL mmol) and potassium carbonate (95.0 g, 687 mmol) were sequentially added to a solution of (7-bromo-3-nitroquinolin-4-yl)(4,4-dimethoxybutyl)amine in dichloromethane and stirred overnight at ambient temperature. The layers were separated and the organic layer was washed sequentially with water (5×200 mL), saturated aqueous sodium bicarbonate, and brine, dried over magnesium sulfate, and concentrated under reduced pressure to afford 59.3 g of 7-bromo-N4-(4,4-dimethoxybutyl)quinoline-3,4 diamine as a brown oil.

Provenance & Evidence